Graze Lab | Functional and Quantitative Genomics
Our research addresses functional genomic, quantitative genetic and evolutionary questions, with a focus on the role of gene regulation. We use Drosophila as a model system and a variety of genetic, genomic and bioinformatic tools are employed to understand the role of gene regulation in complex trait variability.
Individuals in populations (be they fruit flies or people) vary in gene expression. Only some of this variability contributes to differences in higher level phenotypes. Functional genomic studies within populations and across species help us understand how variability and the evolution of species differences are affected by the underlying genetic pathways.
More broadly, functional genomic studies of complex traits can inform predictive genotype to phenotype maps and improve the transfer of this genetic knowledge from Drosophila to other systems.